Diarrhea or constipation? Maintaining a healthy gut microbiota is crucial!
The gut microbiota plays a crucial role in maintaining intestinal health.
Under normal conditions, a balance exists within the gut between beneficial and harmful bacteria. When beneficial bacteria dominate, the equilibrium of the gut microbiota is maintained, supporting normal intestinal function. However, when the number of beneficial bacteria decreases and harmful bacteria increase, this balance is disrupted, potentially leading to issues such as constipation or diarrhea.
A reduction in beneficial bacteria and an increase in harmful bacteria can slow down intestinal peristalsis, causing food residue to remain in the intestines for an extended period. This leads to excessive water absorption, resulting in hardened stools that are difficult to eliminate.
Simultaneously, an increase in harmful bacteria can trigger inflammatory and immune responses, leading to intestinal dysfunction and, consequently, diarrhea.
Therefore, maintaining a healthy microbial community within the human gut is essential for overall health.
Scientific experiments on Bioyitech's functional strains to promote intestinal peristalsis.
Patent: Bifidobacterium animalis subsp. lactis F1-7 for Promoting Intestinal Peristalsis and Its Application
Patent Number: ZL202110565814.X
Objective of the Invention
· To obtain a single bacterial strain with outstanding probiotic properties and the ability to effectively promote intestinal peristalsis.
· To provide a subspecies of Bifidobacterium animalis,F1-7, for promoting intestinal peristalsis and its application.
Verification Experiments
Animal experiments (zebrafish, mice) were divided into normal group (N), model group (M), model + drug group (P), model + LGG group, and model + F1-7 group.
Bacterial suspensions with a concentration of 108 CFU/mL were used for immersion of constipated zebrafish for 24 hours. The number of intestinal peristalsis in zebrafish in each group within a unit time (1 min) was observed under an inverted fluorescence microscope.
After inducing intestinal peristalsis disorder in mice, probiotic intervention was carried out for 20 days. After the intervention, the intestinal transit rate of the mice was observed.
Two intestinal peristaltic peaks appeared within 1 min in the animal experiment.
N: Normal group, M: Model group, P: Model + positive drug group, LGG: Model + LGG group, F1-7: Model + F1-7 group
In the 1-minute observation of intestinal peristalsis:
Normal group: The first peristaltic peak of zebrafish intestinal peristalsis appeared at about 28 seconds.
Model group: No peristalsis was observed within 1 minute.
Model + positive drug group: The first peristalsis appeared at about 22 seconds, and the second peristalsis appeared at about 42 seconds.
Model + LGG group: No peristalsis was observed within 1 minute.
Model + F1-7 group: The first peristalsis appeared at about 22 seconds, and the second peristalsis appeared at about 42 seconds.
Conclusion: F1-7 can promote intestinal peristalsis and is superior to the LGG group and comparable to positive drugs.
Intestinal Propulsion Effect of F1-7
N: Normal group, M: Model group, P: Model + positive drug group, LGG: Model + LGG group, F1-7: Model + F1-7 group
Intestinal propulsion rate:
Tests were performed 15 minutes after feeding, intestinal propulsion rate = (distance of food movement / total length of small intestine) * 100%
Compared with the model group, F1-7 significantly promoted the intestinal transit rate of mice, increasing from 1.04 ± 1.81% to 88.19 ± 4.10% (p < 0.01), which is close to the level of positive drugs and superior to the model strain LGG.
Conclusion: The intestinal propulsion effect of Bifidobacterium Animalis Subspecies F1-7 is close to that of positive drugs and has a significant intestinal propulsion effect.