The Gut: The Health Center of the Human Body

The gut is a vital digestive organ, responsible not only for nutrient absorption (approximately 99% of nutrients are absorbed here) but also serving as the body's primary detoxification center (over 80% of toxins are expelled via the gut). It also acts as a barrier against bacterial invasion. Possessing a rich network of nerve cells, it can make independent judgments and issue commands to the body, earning it the moniker the second brain.

Modern medical research indicates that the gut, through its microbiome, plays a complex role in physiological functions such as endocrine hormone regulation, immune responses, and metabolic product transformation. It is intricately linked to the functional regulation of the liver, kidneys, and even the brain, forming the gut-X axis. Consequently, many chronic diseases are closely associated with the gut and its microbial inhabitants. As the gut-X axis gains wider recognition and acceptance, gut health has emerged as a paramount concern in contemporary human health discussions.

How to maintain the Gut Health

Balanced Diet:

Consume high-fiber foods (such as vegetables, fruits, and whole grains) to maintain nutritional balance and promote gut health.

Adequate Hydration:

Sufficient fluid intake helps prevent constipation and supports normal gut function.

Stress Reduction:

Chronic stress is detrimental to gut health; actively seek effective stress management techniques.

Regular Bowel Movements:

Maintain a regular defecation pattern and avoid stool retention. Prudent Antibiotic Use: Employ antibiotics judiciously to prevent adverse effects on the gut microbiota.

Probiotic Supplementation:

Timely supplementation with Probiotics like Bifidobacterium animalis subsp. Lactis F1-7 and Lacticaseibacillus paracasei X11, along with prebiotics (e.g., yogurt, fermented foods, probiotic supplements), can balance gut flora and maintain microbial homeostasis.

Patent: Bifidobacterium animalis subsp. lactis F1-7 for Promoting Intestinal Peristalsis and Its Application

Patent Number: ZL202110565814.X

Objective of the Invention

• To obtain a single bacterial strain with outstanding probiotic properties and the ability to effectively promote intestinal peristalsis.
• To provide a subspecies of Bifidobacterium animalis, F1-7, for promoting intestinal peristalsis and its application.

Verification Experiments

Animal experiments (zebrafish, mice) were divided into normal group (N), model group (M), model + drug group (P), model + LGG group, and model + F1-7 group.

Bacterial suspensions with a concentration of 108 CFU/mL were used for immersion of constipated zebrafish for 24 hours. The number of intestinal peristalsis in zebrafish in each group within a unit time (1 min) was observed under an inverted fluorescence microscope.

After inducing intestinal peristalsis disorder in mice, probiotic intervention was carried out for 20 days. After the intervention, the intestinal transit rate of the mice was observed.

Two intestinal peristaltic peaks appeared within 1 min in the animal experiment.

N: Normal group, M: Model group, P: Model + positive drug group, LGG: Model + LGG group, F1-7: Model + F1-7 group

In the 1-minute observation of intestinal peristalsis:

Normal group: The first peristaltic peak of zebrafish intestinal peristalsis appeared at about 28 seconds.

Model group: No peristalsis was observed within 1 minute.

Model + positive drug group: The first peristalsis appeared at about 22 seconds, and the second peristalsis appeared at about 42 seconds.

Model + LGG group: No peristalsis was observed within 1 minute.

Model + F1-7 group: The first peristalsis appeared at about 22 seconds, and the second peristalsis appeared at about 42 seconds.

Conclusion: F1-7 can promote intestinal peristalsis and is superior to the LGG group and comparable to positive drugs.

Gut health is indispensable for overall bodily well-being. A consistent diet, regular physical activity, routine medical check-ups, and interventions with microecological agents are the best assurances for optimal gut function.