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Bone Health Probiotics Premix - 500B | China Suppliers & Factory for Optimal Nutritional Support

Deposite: CCTCC M 2020833

Shelf life: 24 months

Storage conditions: Stored at -18℃or lower

Health Benefits
Introducing our premium range of products sourced directly from reliable suppliers in China. Our factory is committed to delivering high-quality items that meet international standards. By partnering with top China suppliers, we ensure that every product is crafted with precision and care, making us a trusted choice for customers worldwide. Explore our extensive collection and experience the excellence that comes from our dedicated factory. Discover the benefits of sourcing from China today!
  • ● Bifidobacterium animalis subsp. lactis F1-7
  • ● Bifidobacterium animalis subsp. lactis BA-C53
  • ● Lactiplantibacillus plantarum YZX21
  • ● Lacticaseibacillus paracasei X11
  • ● Lactobacillus acidophilus LA-C29
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Product Detail

Health Benefits

Fermented Carrot Juice (Non-Live Bacteria) (3)lqr
  • Alleviate osteoporosis
  • Relieve inflammation
  • Promote intestinal calcium absorption
  • Activate the gut-bone axis
  • Enhance immunity
  • Alleviate bone loss

The essence of bone metabolism: Dynamic balance of osteoclasts and osteoblasts

Bone Health

The processes of bone resorption and remodeling are lifelong dynamic phenomena, characterized by a delicate equilibrium between the activity of osteoclasts, which mediate bone resorption, and osteoblasts, which facilitate bone deposition. By the age of 20, bone mass reaches approximately 90% of its peak adult value.

Subsequently, during the third decade of life, bone mass may increase by an additional 10%. However, from the age of 35 onwards, a gradual decline in bone mass begins in both men and women, coinciding with a decrease in sex hormone levels.

As the human body ages, the persistent decline in hormone levels leads to further bone loss, particularly in women approaching menopause, where the rate of bone density reduction accelerates, placing them at a higher risk for osteoporosis compared to men, thereby increasing the likelihood of fractures.

Bone Health1

Probiotics can improve bone health

Numerous research findings indicate that the supplementation of probiotics may offer potential benefits for the preservation of bone health, both in healthy and pathological contexts.

Observations of skeletal improvements have been noted across various osteoporosis animal disease models subjected to probiotic interventions. Probiotics may contribute to the maintenance of bone health by modulating gut immunity and alleviating inflammatory responses.

Bone Health2

In recent years, the relationship between gut microbiota and bone metabolism has garnered increasing attention. The gut microbiota can influence distant skeletal health through various mechanisms, including the modulation of the immune system. Previous research has clearly established the connection between the immune system and bone loss, indicating that abnormal activation of the gut immune system can significantly impact bone health.

Bifidobacterium animalis subsp. lactis F1-7 balances bone metabolism and improves osteoporosis

Bone Health3

Intestinal health is closely related to bone metabolism: impaired intestinal barrier → increased intestinal permeability → intestinal inflammation → osteoclast overproduction → bone loss → osteoporosis

Bone Health4
The histological examination of femoral tissue using H&E staining provides a clear visualization of the alterations in the microstructure of trabecular bone within the medullary cavity. This approach aids in the further assessment of the status of bone microarchitecture, allowing for a comprehensive analysis of the changes in trabecular bone microstructure within the medullary cavity to evaluate the condition of bone microarchitecture.
Bone Health5
Compared to the sham surgery group, the OVX group mice exhibited significant deterioration in the microstructure of the femur: the trabecular bone became thinner, its density decreased, and the arrangement became sparse. However, the interventions with strains FL228.1 and F1-7 contributed to the improvement of the trabecular microstructure, thereby aiding in the amelioration of osteoporosis.
Bone Health6
BMD reflects the bone mineral density of the femur, while BV/TV indicates changes in bone volume, both of which typically decrease in cases of osteoporosis. Tb.N, Tb.Sp, and SMI describe the spatial morphological structure of trabecular bone. In osteoporotic conditions, Tb.N tends to decrease, whereas Tb.Sp correspondingly increases. SMI provides a description of the ratio of plate-like to rod-like structures within the trabecular architecture, and its value is associated with measurements of surface convexity. This parameter is crucial in the osteoporotic degeneration of trabecular bone. In osteoporosis, SMI generally shows an upward trend.
Bone Health7
The TRAP staining results indicate that following ovariectomy, there is a significant increase in the number of osteoclasts in the femurs of mice, and various probiotic strains exhibit differing degrees of inhibitory effects on osteoclastogenesis.

Literature

  • Lu Y, Zhang Y, Zhang J, et al. Konjac glucomannan with probiotics acts as a combination laxative to relieve constipation in mice by increasing short-chain fatty acid metabolism and 5-hydroxytryptamine hormone release[J]. Nutrition, 2021, 84(1).
  • Lu Y, Zhang J, Yi H, et al. Screening of intestinal peristalsis-promoting probiotics based on a zebrafish model[J]. Food & Function, 2019, 10. DOI:10.1039/C8FO02523A.
  • Cao J, Liu Q, Hao H, et al. Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice[J]. Frontiers in Immunology, 2022, 13. DOI:10.3389/fimmu.2022.940228.
  • Lu Y, Zhang J, Zhou X, et al. The edible Lactobacillus paracasei X11 with Konjac glucomannan promotes intestinal motility in zebrafish[J]. Neurogastroenterology & Motility, 2021. DOI:10.1111/nmo.14196.
  • Lu Y, Zhang J, Liang Z, et al. Konjac glucomannan with probiotics acts as a combination laxative to relieve constipation in mice by increasing short-chain fatty acid metabolism and 5-hydroxytryptamine hormone release[J]. Nutrition, 2021, 84(1).
  • Bifidobacterium improves oestrogen-deficiency induced osteoporosis in mice by modulating intestinal immunity.
  • The regulative effect and repercussion of probiotics and prebiotics on osteoporosis: involvement of brain-gut-bone axis.

Frequently Asked Questions

How do probiotics contribute to the preservation of bone health?
Probiotics help maintain bone health by modulating gut immunity, alleviating systemic inflammatory responses, and activating the gut-bone axis. This helps regulate the balance between bone resorption and bone deposition.
What is the relationship between gut health and osteoporosis?
Impaired intestinal barrier function increases intestinal permeability, leading to intestinal inflammation. This inflammatory state triggers the overproduction of osteoclasts (cells that break down bone), resulting in bone loss and eventually osteoporosis.
How does Bifidobacterium animalis subsp. lactis F1-7 improve bone condition?
Studies show that intervention with Bifidobacterium animalis subsp. lactis F1-7 helps improve the microstructure of trabecular bone, increases bone mineral density (BMD), and inhibits excessive osteoclastogenesis to prevent bone loss.
At what age does bone mass naturally begin to decline?
Bone mass reaches about 90% of its peak by age 20 and increases slightly until the age of 30. From the age of 35 onwards, a gradual and natural decline in bone mass begins in both men and women due to falling hormone levels.
Why are menopausal women at higher risk of osteoporosis?
During menopause, sex hormone (estrogen) levels drop rapidly. This hormonal change accelerates bone density reduction, placing women at a significantly higher risk for osteoporosis and fractures compared to men.

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