Bone Health Probiotics Premix 500B - Top China Suppliers & Factory for Enhanced Nutritional Support
Deposite: CCTCC M 2020833
Shelf life: 24 months
Storage conditions: Stored at -18℃or lower
Health Benefits
Health Benefits
- Alleviate osteoporosis
- Relieve inflammation
- Promote intestinal calcium absorption
- Activate the gut-bone axis
- Enhance immunity
- Alleviate bone loss
The essence of bone metabolism: Dynamic balance of osteoclasts and osteoblasts
The processes of bone resorption and remodeling are lifelong dynamic phenomena, characterized by a delicate equilibrium between the activity of osteoclasts, which mediate bone resorption, and osteoblasts, which facilitate bone deposition. By the age of 20, bone mass reaches approximately 90% of its peak adult value.
Subsequently, during the third decade of life, bone mass may increase by an additional 10%. However, from the age of 35 onwards, a gradual decline in bone mass begins in both men and women, coinciding with a decrease in sex hormone levels.
As the human body ages, the persistent decline in hormone levels leads to further bone loss, particularly in women approaching menopause, where the rate of bone density reduction accelerates, placing them at a higher risk for osteoporosis compared to men, thereby increasing the likelihood of fractures.
Probiotics can improve bone health
Numerous research findings indicate that the supplementation of probiotics may offer potential benefits for the preservation of bone health, both in healthy and pathological contexts.
Observations of skeletal improvements have been noted across various osteoporosis animal disease models subjected to probiotic interventions. Probiotics may contribute to the maintenance of bone health by modulating gut immunity and alleviating inflammatory responses.
In recent years, the relationship between gut microbiota and bone metabolism has garnered increasing attention. The gut microbiota can influence distant skeletal health through various mechanisms, including the modulation of the immune system. Previous research has clearly established the connection between the immune system and bone loss, indicating that abnormal activation of the gut immune system can significantly impact bone health.
Bifidobacterium animalis subsp. lactis F1-7 balances bone metabolism and improves osteoporosis
Intestinal health is closely related to bone metabolism:
The histological examination of femoral tissue using H&E staining provides a clear visualization of the alterations in the microstructure of trabecular bone within the medullary cavity. This approach aids in the further assessment of the status of bone microarchitecture, allowing for a comprehensive analysis of the changes in trabecular bone microstructure within the medullary cavity to evaluate the condition of bone microarchitecture.
Compared to the sham surgery group, the OVX group mice exhibited significant deterioration in the microstructure of the femur: the trabecular bone became thinner, its density decreased, and the arrangement became sparse. However, the interventions with strains FL228.1 and F1-7 contributed to the improvement of the trabecular microstructure, thereby aiding in the amelioration of osteoporosis.
BMD reflects the bone mineral density of the femur, while BV/TV indicates changes in bone volume, both of which typically decrease in cases of osteoporosis. Tb.N, Tb.Sp, and SMI describe the spatial morphological structure of trabecular bone. In osteoporotic conditions, Tb.N tends to decrease, whereas Tb.Sp correspondingly increases. SMI provides a description of the ratio of plate-like to rod-like structures within the trabecular architecture, and its value is associated with measurements of surface convexity. This parameter is crucial in the osteoporotic degeneration of trabecular bone. In osteoporosis, SMI generally shows an upward trend.
The TRAP staining results indicate that following ovariectomy, there is a significant increase in the number of osteoclasts in the femurs of mice, and various probiotic strains exhibit differing degrees of inhibitory effects on osteoclastogenesis.
Literature
- Lu Y, Zhang Y, Zhang J, et al. Konjac glucomannan with probiotics acts as a combination laxative to relieve constipation in mice by increasing short-chain fatty acid metabolism and 5-hydroxytryptamine hormone release[J]. Nutrition, 2021, 84(1).
- Lu Y, Zhang J, Yi H, et al. Screening of intestinal peristalsis-promoting probiotics based on a zebrafish model[J]. Food & Function, 2019, 10. DOI:10.1039/C8FO02523A.
- Cao J, Liu Q, Hao H, et al. Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice[J]. Frontiers in Immunology, 2022, 13. DOI:10.3389/fimmu.2022.940228.
- Lu Y, Zhang J, Zhou X, et al. The edible Lactobacillus paracasei X11 with Konjac glucomannan promotes intestinal motility in zebrafish[J]. Neurogastroenterology & Motility, 2021. DOI:10.1111/nmo.14196.
- Lu Y, Zhang J, Liang Z, et al. Konjac glucomannan with probiotics acts as a combination laxative to relieve constipation in mice by increasing short-chain fatty acid metabolism and 5-hydroxytryptamine hormone release[J]. Nutrition, 2021, 84(1).
- Bifidobacterium improves oestrogen-deficiency induced osteoporosis in mice by modulating intestinal immunity. The regulative effect and repercussion of probiotics and prebiotics on osteoporosis: involvement of brain-gut-bone axis.