Lacticaseibacillus paracasei G15 Pet Probiotics Powder - China Suppliers Factory | CCTCC M 20232497
Deposite: CCTCC M 2020833
Shelf life: 24 months
Storage conditions: Stored at -18℃or lower
Health Benefits
Detailed Information
Applications
Dairy
Food
Fermented Beverages
Pharmaceuticals
Biotechnology
Feed Additive/Pet
Literature
- 1. Antidiabetic (type 2) effects of Lactobacillus G15 and Q14 in rats through regulation of intestinal permeability and microbiota.
- 2. Targeting gut microbiota Lactobacillus alleviated type 2 diabetes via inhibiting LPS secretion and activating GPR43 pathway.
Academic Research
Background
- The prevalence of type 2 diabetes (T2D) is increasing and the search for new therapeutic approaches is crucial.
- Gut flora plays an important role in the pathogenesis of T2D, influencing disease progression by regulating energy metabolism, insulin resistance, and inflammation, among other pathways.
- Probiotics, especially lactobacilli, have been shown to have beneficial effects on diabetes-related parameters, but their mechanism of action is unclear.
- The aim of this study was to evaluate the effects of two lactic acid bacteria (G15 and Q14) isolated from traditional Chinese fermented dairy products on T2D and their mechanisms.
Research Methods
- The researchers used a high-fat diet and a streptozotocin-induced T2D rat model.
- The experiment was divided into 7 groups: normal control, diabetic control, metformin-treated, G15-treated, G15+metformin-treated, Q14-treated and Q14+metformin-treated.
- Researchers assessed the effects of probiotics on blood glucose tolerance, gut flora, gut permeability, inflammation and islet damage.
Study Results
- G15 and Q14 significantly improved blood glucose tolerance and lowered glycated haemoglobin (HbA1c) levels in T2D rats, suggesting their antidiabetic effects.
- Probiotic treatment reduced intestinal permeability and improved epithelial barrier function by modulating intestinal flora, thereby reducing circulating LPS and inflammatory cytokines (e.g., IL-1β and IL-8), and ultimately attenuating inflammatory state and pancreatic islet β-cell dysfunction.
- Combination treatment of Q14 with metformin reversed thymic atrophy, while both G15 and Q14 reduced circulating levels of IL-6, suggesting the immunomodulatory potential of these strains.
Conclusions
- G15 and Q14 have antidiabetic effects in T2D rats through the regulation of gut flora, intestinal permeability and inflammation pathways.
- These results provide new ideas for the biotherapeutic application of traditional fermented foods and their functional components in the treatment of diabetes.
Significance of the Study
- This study reveals the link between intestinal flora and T2D, and provides a theoretical basis for the development of novel diabetes treatments.
- Probiotics, as functional components of traditional fermented foods, have potential applications in the treatment of diabetes.
Future Research Directions
- Further investigate the interaction mechanism between intestinal flora and epithelial barrier.
- Explore in depth the effects of probiotics on the composition and function of intestinal flora.
- Conduct longer experiments to assess the long-term effects of probiotics on immune-related parameters.
Frequently Asked Questions
What product customization options are available?
We offer customizable solutions for our probiotic products. Available potency options range from 10B CFU/g up to 500B CFU/g (including 50B, 100B, 200B, 300B, and 400B CFU/g) to meet specific formulation requirements.
How should the probiotic powder be stored, and what is its shelf life?
The probiotic powder has a shelf life of 24 months. To maintain maximum viability and stability, it must be stored under frozen conditions at -18℃ or below.
What are the main application fields for Lacticaseibacillus Paracasei G15?
Lacticaseibacillus Paracasei G15 postbiotics powder is highly versatile and suitable for dairy products, food, fermented beverages, pharmaceuticals, biotechnology, and feed additives or pet food.
What academic research supports the antidiabetic effects of G15?
Academic studies demonstrate that Lactobacillus G15 and Q14 exhibit significant antidiabetic (type 2) effects in rat models. The research indicates these strains help regulate intestinal permeability, improve blood glucose tolerance, lower HbA1c levels, and modulate gut microbiota.
How does G15 influence gut barrier function and inflammation?
According to research, treatment with G15 reduces intestinal permeability and enhances epithelial barrier function. This action lowers circulating LPS and inflammatory cytokines (such as IL-1β, IL-6, and IL-8), which helps reduce overall inflammation and pancreatic islet β-cell dysfunction.