Lacticaseibacillus paracasei G15/Pet Probiotics powder

1. Antidiabetic (type 2) effects of Lactobacillus G15 and Q14 in rats through regulation of intestinal permeability and microbiotat.

2.Targeting gut microbiota Lactobacillus alleviated type 2 diabetes via inhibiting LPS secretion and activating GPR43 pathway.

Antidiabetic (type 2) effects of Lactobacillus G15 and Q14 in rats through regulation of intestinal permeability and microbiota’ This research paper examines the antidiabetic effects and possible mechanisms of two Lactobacillus strains ( G15 and Q14) on high-fat diet and streptozotocin-induced type 2 diabetes (T2D) in rats and its possible mechanisms.

Background

* The prevalence of type 2 diabetes (T2D) is increasing and the search for new therapeutic approaches is crucial.

* Gut flora plays an important role in the pathogenesis of T2D, influencing disease progression by regulating energy metabolism, insulin resistance, and inflammation, among other pathways.

* Probiotics, especially lactobacilli, have been shown to have beneficial effects on diabetes-related parameters, but their mechanism of action is unclear.

* The aim of this study was to evaluate the effects of two lactic acid bacteria (G15 and Q14) isolated from traditional Chinese fermented dairy products on T2D and their mechanisms.

Research Methods

* The researchers used a high-fat diet and a streptozotocin-induced T2D rat model.

* The experiment was divided into 7 groups: normal control, diabetic control, metformin-treated, G15-treated, G15+metformin-treated, Q14-treated and Q14+metformin-treated.

* Researchers assessed the effects of probiotics on blood glucose tolerance, gut flora, gut permeability, inflammation and islet damage.

Study results

* G15 and Q14 significantly improved blood glucose tolerance and lowered glycated haemoglobin (HbA1c) levels in T2D rats, suggesting their antidiabetic effects.

* Probiotic treatment reduced intestinal permeability and improved epithelial barrier function by modulating intestinal flora, thereby reducing circulating LPS and inflammatory cytokines (e.g., IL-1β and IL-8), and ultimately attenuating inflammatory state and pancreatic islet β-cell dysfunction.

* Combination treatment of Q14 with metformin reversed thymic atrophy, while both G15 and Q14 reduced circulating levels of IL-6, suggesting the immunomodulatory potential of these strains.

Conclusions

* G15 and Q14 have antidiabetic effects in T2D rats through the regulation of gut flora, intestinal permeability and inflammation pathways.

* These results provide new ideas for the biotherapeutic application of traditional fermented foods and their functional components in the treatment of diabetes.

Significance of the study

* This study reveals the link between intestinal flora and T2D, and provides a theoretical basis for the development of novel diabetes treatments.

* Probiotics, as functional components of traditional fermented foods, have potential applications in the treatment of diabetes.

Future Research Directions

* Further investigate the interaction mechanism between intestinal flora and epithelial barrier.

* Explore in depth the effects of probiotics on the composition and function of intestinal flora.

* Conduct longer experiments to assess the long-term effects of probiotics on immune-related parameters.