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Bioyitech's experiment screened bacterial strains that promote GLP-1 secretion.
Bioyitech focuses on functional Probiotic Strains that improve "sugar-lipid metabolism," and is committed to improving endogenous metabolic capacity through probiotics.Bioyitech's research focuses on discovering probiotics that can stimulate the secretion of endogenous GLP-1 and exploring their mechanisms, which is also a key condition for Bioyitech to screen "blood sugar-lowering" strains.
In vitro screening of probiotics for their ability to modulate GLP-1 secretion.
The ability of probiotics to modulate GLP-1 was determined by constructing STC-1 cells. It was observed that the Bifidobacterium animalis F1-7 group had the highest GLP-1 secretion, at 19.66±0.18 ng/ml, with the most significant effect. Lactobacillus plantarum YZX21 was not much different, following closely behind. Bifidobacterium animalis F1-7 significantly affected the expression of GCG and PC3 genes, with an upregulation of more than 2 times, significantly higher than other groups, indicating that Bifidobacterium animalis F1-7 and Lactobacillus plantarum YZX21 are the two strains we screened for high GLP-1 expression!
Effects of F1-7 and YZX21 on blood glucose in type 2 diabetes
Fasting blood glucose (>7.0 mmol/L) and postprandial blood glucose (>11.1 mmol/L) in diabetic mice were significantly increased; after supplementation with probiotics, fasting blood glucose and postprandial blood glucose in mice were significantly reduced, with fasting blood glucose in the F1-7 intervention group decreasing from 12.26 mmol/L to 7.13 mmol/L, a reduction rate of 41.84%. Postprandial blood glucose levels decreased from 24.68 mmol/L to 10.95 mmol/L, a reduction rate of 47.53%, close to normal levels. Further, the oral glucose tolerance test (OGTT) was used to detect the function of pancreatic β cells in the body, and the area under the blood glucose curve in the diabetic group was significantly higher than that in the control group; after supplementation with probiotics, the glucose tolerance improvement effect was best in the F1-7 group, followed by the YZX21 group.
F1-7 and YZX21 not only improve the gene expression of endogenous GLP-1, but also restore the damaged cell morphology.
The volume of islet cells in diabetic mice was reduced, indicating that intervention withBifidobacterium animalis subsp. lactis F1-7 and Lactiplantibacillus plantarum YZX21 could restore cell morphology.
Insulin signals in diabetic mice were reduced, and glucagon increased. This indicates that Bifidobacterium animalis F1-7 and Lactobacillus plantarum YZX21 increased insulin secretion and decreased glucagon secretion.
Effects of F1-7 and YZX21 on GLP-1 secretion and gene expression in type 2 diabetes
The GLP-1 content in the intestine of diabetic mice was reduced, and the F1-7 group could increase the expression of GCG and PC3 genes, restore the number of GLP-1 positive cells, and increase the GLP-1 content in the colon from 4.23 pmol/L to 11.65 pmol/L. YZX21 was also similar, indicating that F1-7 and YZX21 can improve type 2 diabetes by regulating intestinal GLP-1 secretion.
In summary, Bifidobacterium animalis F1-7 and Lactobacillus plantarum YZX21 can protect islet cells, improve insulin secretion, and reduce insulin resistance in the body.
The above experimental data show that Bioyitech’s Bifidobacterium animalis subsp. lactis F1-7 and Lactiplantibacillus plantarum YZX21 can increase the secretion of endogenous GLP-1 and improve type 2 diabetes through the functional targets of GLP-1.
Through endogenous regulation of probiotics and Improve blood sugar and promote health
With a deeper understanding of the causes and pathogenesis of diabetes, as well as the wide application and research progress of probiotics in the treatment of diabetes, the prospects of probiotics in the treatment of diabetes are becoming wider and wider.
Compared with traditional drug treatment, probiotics regulate the intestinal balance and stimulate the body's endogenous metabolic capacity. They are attracting people's attention due to their advantages of long-lasting efficacy, fewer side effects, and less recurrence.
However, the prevention and treatment of diabetes cannot rely solely on drugs or probiotics. It is also very important to improve one's own lifestyle, including a reasonable diet, moderate exercise, weight control, and smoking and alcohol cessation. For high-risk populations, such as those with a family history of diabetes, screening and prevention should be carried out as early as possible.