China Probiotics Premix 500B for Gut Health - Trusted Suppliers & Quality Factory Solutions
Deposite: CCTCC M 2020833
Shelf life: 24 months
Storage conditions: Stored at -18℃or lower
Health Benefits
Health Benefits
- ✓Increase intestinal peristalsis frequency
- ✓Enhance intestinal propulsive force
- ✓Increase stool water content, improve constipation
- ✓Improve intestinal mucosal structure, tight junction protein system, mucosal permeability, and inflammatory markers
- ✓Restore intestinal flora
Gut Health and Probiotics
The mechanism of probiotics
Probiotics, on the other hand, affect the intestinal ecosystem by influencing mucosal immune mechanisms, interacting with intestinal commensals or potentially pathogenic microorganisms, producing metabolic end products (e.g., short-chain fatty acids), and communicating with host cells through chemical signalling.
These mechanisms of action may contain potentially pathogenic bacteria, modulate the microbiome, physiological stress protection, enhance intestinal barrier function, down-regulate inflammation and up-regulate immune responses after exposure to antigens.
Single strain profile
Intestinal motility and health
Intestinal peristalsis refers to the wave-like contractions of the intestines that resemble the movement of worms.
Prolonged slowing of peristalsis can lead to gastrointestinal disorders such as intestinal obstruction and constipation, and may also trigger cardiovascular and cerebrovascular diseases.
During the 1-minute observation of intestinal peristalsis:
- ⏱Normal group: The first peak of peristaltic waves in zebrafish intestines appears around 28 seconds.
- ⏱Model group: No peristaltic activity was observed within 1 minute.
- ⏱Model + Positive Drug Group: The first peristaltic wave occurs around 22 seconds, followed by a second wave at approximately 42 seconds.
- ⏱Model + LGG Group: No peristaltic activity was observed within 1 minute.
- ⏱Model + F1-7 Group: The first peristaltic wave appears around 22 seconds, with a second wave occurring at approximately 42 seconds.
Prolonged slowing of peristalsis can lead to gastrointestinal disorders such as intestinal obstruction and constipation, and may also trigger cardiovascular and cerebrovascular diseases.
The experimental conclusion:
F1-7 inhibits the overexpression of AQP3 protein, preventing excessive water absorption in intestinal epithelium.
The experimental conclusion:
F1-7 promotes the expression levels of colonic AQP3 protein towards normalcy, alleviating constipation caused by the overexpression of AQP3 protein.
The experimental conclusion is as follows:
The protein expression level of MUC-2 was the lowest in the model group, while it significantly increased in both the normal group and the intervention group.
After the intervention with the KGM+F1-7 composition, the upregulation effect of MUC-2 protein levels was found to be the most significant.
Intestinal epithelium: The epithelium, consisting of absorptive cells, cup cells and a small number of endocrine cells, has the functions of nutrient digestion and absorption, barrier and immune defence, absorption and secretion of water and electrolytes, and synthesis of several bioactive amines and peptides.
Conclusion:
Compared with the control group, the intestinal tract of the model group lost its complete structure, the intestinal epithelium was folded and disordered, and the intestinal muscle layer almost disappeared. In contrast, the intestinal mucosa of the intervention group folded relatively regularly and the intestinal muscle layer was intact.
The number of epithelial cells in the model group was low, whereas the number of epithelial cells was relatively high in all the different intervention groups.
