Metaboled™ Clinical Study Uncovers Multi‑metabolic Benefits for Type 2 Diabetic Subjects: Weight Loss, Lipid Regulation and Improved Insulin Sensitivity

Yike Biotech has officially released the full clinical data from its randomized, double-blind, placebo-controlled human feeding trial of Metaboled™ Compound Lactic Acid Bacteria Powder. The clinical research was designed to evaluate the effects of the proprietary probiotic formulation on core metabolic indicators, including body weight, body mass index (BMI), lipid panel, glycemic health markers, insulin levels, C-peptide, and HOMA-IR. The study provides robust, human clinical evidence supporting the application of Metaboled™ as a functional probiotic ingredient for metabolic health and weight management formulations.

This human clinical trial enrolled 60 participants with impaired metabolic health conditions, conducted under rigorous randomized, double-blind, placebo-controlled research standards to ensure data authenticity and scientific validity.

After 90 days of consistent supplementation, the Metaboled™ intervention group achieved an average weight reduction of 3.66kg compared with baseline data. Participants’ BMI decreased from 26.47 to 25.06, a total reduction of 1.41 points — nearly double the improvement observed in the placebo group.

The average body weight of the treatment group dropped from 72.55kg (baseline) to 68.77kg at the end of the trial. Notably, statistically significant inter-group differences in weight management effects were observed as early as Day 30 (p=0.0468), proving that this Multi-Strain probiotic blend can trigger positive metabolic responses in a short intervention cycle.

Most metabolic functional ingredients require long-term intake to produce measurable physical improvements. In this trial, distinct group differences in weight indicators emerged within 30 days, with more prominent weight and BMI optimization effects after 90 days of supplementation. The results fully demonstrate the strong application potential of this compound lactic acid bacteria formula for healthy weight management scenarios.

Clinical test data verified that continuous Metaboled™ supplementation effectively optimizes core blood lipid indicators, including the reduction of low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB).

LDL-C and ApoB are critical biomarkers closely associated with vascular metabolic health. By regulating these key metabolic indicators, the multi-strain probiotic formula modulates lipid metabolism through multiple pathways, helps reduce abnormal lipid accumulation, and supports long-term vascular and metabolic homeostasis.

Insulin sensitivity is a core indicator affecting overall metabolic balance, fat metabolism, and glycemic health.

Starting from Day 60 of the intervention, participants in the Metaboled™ group showed distinctly lower serum insulin and C-peptide levels compared with the placebo group. Meanwhile, the HOMA-IR index presented a statistically significant improvement (p=0.0433).

The clinical results confirm that Metaboled™ effectively enhances peripheral insulin sensitivity. Researchers conclude that improved insulin sensitivity is the core internal mechanism driving optimized body weight, healthy fat metabolism, and balanced lipid profiles, forming synergistic multi-dimensional metabolic health benefits.

The 90-day human clinical trial fully validates that Metaboled™ Compound Lactic Acid Bacteria Powder effectively regulates lipid metabolism, inhibits excessive fat accumulation, and improves insulin sensitivity. It delivers dual functional values of stabilizing healthy weight fluctuations and optimizing body composition.

As a scientifically verified multi-strain compound probiotic ingredient, Metaboled™ serves as an effective nutritional intervention solution for metabolic health maintenance, suitable for developing high-end weight management and metabolic health Dietary Supplements beyond daily dietary adjustment.

Metaboled™ is a patented compound lactic acid bacteria ingredient independently developed by Yike Biotech, exclusively tailored for metabolic health and healthy weight management product formulations. Yike Biotech provides global B2B professional services, including standardized probiotic raw material supply, customized formula development, and full-process OEM/ODM manufacturing solutions for dietary supplement brands and manufacturers worldwide.