World Immunization Strengthening Day: Gut Microbiota Aids Immune Capacity Enhancement
As the first winter post-pandemic arrives, infectious diseases such as COVID-19, influenza, respiratory syncytial virus, and mycoplasma pneumoniae are emerging.
On December 15th, 《World Immunization Strengthening Day》 topics related to enhancing human immunity and resisting infectious disease invasion are once again being highlighted, drawing significant attention.
Gut Microbiota and Immune Health
Our intestines are not sterile environments. In addition to food and metabolic byproducts, they harbor a vast community of microorganisms, predominantly bacteria, which constitute 78% of the total human microbial load, collectively forming the gut microbiota.
Modern medical research indicates that the gut, through its microbiota, plays a crucial role in a complex array of physiological functions, including endocrine hormone regulation, immune responses, and metabolic conversion. It is also intimately linked to the functional regulation of the liver, kidneys, and even the brain.
Consequently, the gut is the largest immune organ in the human body, housing over 70% of the body's immune system. Immune cells such as T cells, B cells, and NK cells, as mentioned previously, are concentrated along the intestinal mucosa.
The gut is also a vital site for the activity of Probiotics likeBifidobacterium animalis subsp. Lactis F1-7 and Lactiplantibacillus plantarum F3-2. Probiotics can improve dysbiosis and establish a biological barrier against intestinal pathogens by mechanisms such as competitive exclusion, nutrient competition, secretion of inhibitory or bactericidal substances, and antagonism of pathogenic bacteria and other microorganisms.
Probiotics Enhance Immunity
Comparative Experiments on Probiotic-Enhanced Immunity
BA-C44 increases beneficial gut bacteria and maintains microbial balance.
Mechanisms of Probiotic-Enhanced Immunity
BifidoBacterium Longum BL-C27 Enhances Immunity and Regulates Gut Microbiota
Mechanisms of Probiotic-Enhanced Immunity
Bifidobacterium longum BL-C27 Enhances Immunity and Regulates Gut Microbiota
Bifidobacterium longum can effectively prevent gut-brain axis diseases and autoimmune diseases. This is attributed to the interaction of Bifidobacterium longum's surface-associated proteins, exopolysaccharides, or metabolites with the host, mediating host health regulation through direct or indirect pathways.
Mechanisms of Bifidobacterium longum-Enhanced Immunity:
- Promotes the growth of immune organs, thereby enhancing non-specific immune function.
- Induces delayed-type hypersensitivity reactions, promoting cellular immunity.
- Enhances the phagocytic capacity of macrophages for foreign substances, boosting non-specific immunity.
- Promotes humoral immune function.
- Enhances the immune response of T lymphocytes.
Mechanisms of Bifidobacterium breve BB-C45-Enhanced Immunity
Following colonization and adhesion in the infant and adult gut, *Bifidobacterium breve* can increase natural killer cell activity, enhance cytokine expression levels, and promote immunoglobulin expression, thereby strengthening the host's immune system function.
Ingestion of preparations containing *Bifidobacterium breve* can stimulate immunoglobulin IgA production, promote increased levels of cytokines such as interleukin-4 and interleukin-10, thus exerting immunomodulatory effects and improving mucosal immunity in breastfed infants.
Research indicates that *Bifidobacterium breve* ingestion can produce antimicrobial substances, reduce pathogen colonization levels, enhance barrier function, and regulate epithelial cell signal transduction and innate and adaptive immune regulation, ultimately bolstering host immune capacity.