Bone Health / ZC-SKE/ Probiotics Premix/500B
Shelf life: 24 months
Storage conditions: Stored at -18℃or below
Main Strains
Health Benefits
● Alleviate osteoporosis
● Relieve inflammation
● Promote intestinal calcium absorption
● Activate the gut-bone axis
● Enhance immunity
● Alleviate bone loss
The essence of bone metabolism: Dynamic balance of osteoclasts and osteoblasts
The processes of bone resorption andremodeling are lifelong dynamicphenomena, characterized by a delicateequilibrium between the activity ofosteoclasts, which mediate bone resorption,and osteoblasts, which facilitate bonedeposition. By the age of 20, bone massreaches approximately 90% of its peakadult value.
Subsequently, during the third decade oflife, bone mass may increase by anadditional 10%. However, from the age of35 onwards, a gradual decline in bone massbegins in both men and women, coincidingwith a decrease in sex hormone levels.
As the human body ages, the persistentdecline in hormone levels leads to furtherbone loss, particularly in womenapproaching menopause, where the rate ofbone density reduction accelerates, placingthem at a higher risk for osteoporosiscompared to men,thereby increasing thelikelihood of fractures.
Probiotics can improve bone health
Numerous research findings indicate that the supplementation of probiotics may offer potential benefits for the preservation of bone health, both in healthy and pathological contexts.
Observations of skeletal improvements have been noted across various osteoporosis animal disease models subjected to probiotic interventions. Probiotics may contribute to the maintenance of bone health by modulating gut immunity and alleviating inflammatory responses.
In recent years, the relationship between gut microbiota and bone metabolism hasgarnered increasing attention. The gutmicrobiota can influence distant skeletal health through various mechanisms,including the modulation of the immune system. Previous research has clearly established the connection between the immune system and bone loss,indicating that abnormal activation of the gut immune system can significantlyimpact bone health.
Bifidobacterium animalis subsp. lactis F1-7 balances bone metabolism and improves osteoporosis
Intestinal health is closely related to bone metabolism: impaired intestinal barrier → increased intestinal permeability → intestinal inflammation → osteoclast overproduction → bone loss → osteoporosis
The histological examination of femoraltissue using H&E staining provides a clearvisualization of the alterations in themicrostructure of trabecular bone within themedullary cavity. This approach aids in the further assessment of the status of bonemicroarchitecture, allowing for acomprehensive analysis of the changes intrabecular bone microstructure within the medullary cavity to evaluate the condition of bone microarchitecture.
Compared to the sham surgery group, theOVX group mice exhibited significant deterioration in the microstructure of the femur: the trabecular bone became thinner, its density decreased, and the arrangementbecame sparse. However, the interventionswith strains FL228.1 and F1-7 contributedto the improvement of the trabecularmicrostructure, thereby aiding in theamelioration of osteoporosis.
BMD reflects the bone mineral density of thefemur, while BV/T'V indicates changes in bonevolume, both of which typically decrease incases of osteoporosis. Tb.N, Tb.Sp, and SMIdescribe the spatial morphological structure oftrabecular bone. In osteoporotic conditions,Tb.N tends to decrease, whereas Tb.Spcorrespondingly increases. SMl provides adescription of the ratio of plate-like to rod-likestructures within the trabecular architecture,and its value is associated with measurementsof surface convexity. This parameter is crucialin the osteoporotic degeneration of trabecularbone. In osteoporosis, SMl generally shows anupward trend.
The TRAP staining results indicatethat following ovariectomy, there is asignificant increase in the number ofosteoclasts in the femurs of mice,and various probiotic strains exhibitdiffering degrees of inhibitory effectson osteoclastogenesis.
Literature
1. Lu Y, Zhang Y, Zhang J, et al. Konjac glucomannan with probiotics acts as a combination laxative to relieve constipation in mice by increasing short-chain fatty acid metabolism and 5-hydroxytryptamine hormone release[J]. Nutrition, 2021, 84(1).
2. Lu Y, Zhang J, Yi H, et al. Screening of intestinal peristalsis-promoting probiotics based on a zebrafish model[J].Food & Function, 2019, 10. DOI:10.1039/C8FO02523A.
3. Cao J, Liu Q, Hao H, et al. Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice[J]. Frontiers in Immunology, 2022, 13. DOI:10.3389/fimmu.2022.940228.
4. Lu Y, Zhang J, Zhou X, et al.The edible Lactobacillus paracasei X11 with Konjac glucomannan promotes intestinal motility in zebrafish[J]. Neurogastroenterology & Motility, 2021. DOI:10.1111/nmo.14196.
5. Lu Y, Zhang J, Liang Z, et al. Konjac glucomannan with probiotics acts as a combination laxative to relieve constipation in mice by increasing short-chain fatty acid metabolism and 5-hydroxytryptamine hormone release[J]. Nutrition, 2021, 84(1).
6. Bifidobacterium improves oestrogen-deficiencyinduced osteoporosis in mice by modulating intestinal immunity.
The regulative effect and repercussion of probio tics and prebiotics on osteoporosis: involvement of brain gut-bone axis.