Gut health / ZC-GUT/ Probiotics Premix /500B
Shelf life: 24 months
Storage conditions: Stored at -18℃or below
Main Strains
Health Benefits
● Increase intestinal peristalsis frequency
● Enhance intestinal propulsive force
● Increase stool water content, improve constipation
● Improve intestinal mucosal structure, tight junction protein system, mucosal permeability, and inflammatory markers
● Restore intestinal flora
Gut Health and Probiotics
The mechanism of probiotics
Probiotics, on the other hand, affect theintestinal ecosystem by influencingmucosal immune mechanisms, interactingwith intestinal commensals or potentiallypathogenic microorganisms, producingmetabolic end products (e.g., short-chainfatty acids), and communicating with hostcells through chemical signalling.
These mechanisms of action may containpotentially pathogenic bacteria, modulatethe microbiome, physiological stressprotection, enhance intestinal barrierfunction, down-regulate inflammation andup-regulate immune responses afterexposure to antigens.
Single strain profile
Intestinal motility and health
Intestinal peristalsis refers tothe wave-like contractions ofthe intestines that resemblethe movement of worms.
Prolonged slowing ofperistalsis can lead togastrointestinal disorderssuch as intestinal obstructionand constipation, and mayalso trigger cardiovascularand cerebrovascular diseases.
During the 1-minute observation of intestinalperistalsis:
Normal group: The first peak of peristalticwaves in zebrafish intestines appears around 28seconds.
Model group: No peristaltic activity wasobserved within 1 minute.
Model + Positive Drug Group: The firstperistaltic wave occurs around 22 seconds,followed by a second wave at approximately 42seconds.
Model + LGG Group: No peristaltic activitywas observed within 1 minute.
Model + F1-7 Group: The first peristaltic waveappears around 22 seconds, with a second waveoccurring at approximately 42 seconds.
Prolonged slowing of peristalsis can lead togastrointestinal disorders such as intestinalobstruction and constipation, and may alsotrigger cardiovascular and cerebrovasculardiseases.
The experimental conclusion:
F1-7 inhibits the overexpression ofAQP3 protein, preventing excessivewater absorption in intestinalepithelium.
The experimental conclusion:
F1-7 promotes the expressionlevels of colonic AQP3 proteintowards normalcy, alleviatingconstipation caused by theoverexpression of AQP3 protein.
The experimental conclusion is asfollows:
The protein expression level ofMUC-2 was the lowest in the modelgroup, while it significantlyincreased in both the normal groupand the intervention group.
After the intervention with theKGM+F1-7 composition, theupregulation effect of MUC-2protein levels was found to be themost significant.
Intestinal epithelium: The epithelium,consisting of absorptive cells, cup cells anda small number of endocrine cells, has thefunctions of nutrient digestion andabsorption, barrier and immune defence,absorption and secretion of water andelectrolytes, and synthesis of severalbioactive amines and peptides.
Conclusion: Compared with the controlgroup, the intestinal tract of the modelgroup lost its complete structure, theintestinal epithelium was folded anddisordered, and the intestinal muscle layeralmost disappeared. In contrast, theintestinal mucosa of the intervention groupfolded relatively regularly and the intestinalmuscle layer was intact.
The number of epithelial cells in the modelgroup was low, whereas the number ofepithelial cells was relatively high in all thedifferent intervention groups.
