Alcohol Metabolism & Liver Protection/ZC-LIV/Probiotics Premix/500B
Shelf life: 24 months
Storage conditions: Stored at -18℃or below
Main Strains
Health Benefits:
● Accelerate metabolism of alcohol in the body
● Increase alcohol tolerance
● Alleviate hangover symptoms
● Protect the liver
● Regulate immune system
Bifidobacterium animalis subsp. lactis KV9 can promote alcohol catabolism
The first step involves the initial breakdown of alcohol: increasing the levels of ADH (alcohol dehydrogenase) in the liver to enhance the metabolism of ethanol in the bloodstream.
The second step, deep decomposition of alcohol: Increase the levels of ALDH (aldehyde dehydrogenase) in the liver to promote the metabolism of acetaldehyde in the bloodstream.
Experimental Study on Bifidobacterium lactis KV9
Hepatic hypertrophy
KV9 can improve liver weight abnormality after drinking
Gnificant macroscopic
Experimental conclusion:
KV9 has the potential to inhibit the increase in liver weight following alcohol consumption, indicating its possible role in mitigating alcohol-induced
hepatic hypertrophy.
Acute alcohol exposure induces significant macroscopic alterations in the liver, which can be quantitatively assessed through liver weight and the liver index. The liver index is defined as the ratio of liver weight to body weight, providing a standardized measure of hepatic mass relative to overall body size. As illustrated in the accompanying figure, alcohol consumption leads to an increase in liver weight, indicating hepatomegaly. Conversely, the administration of KV9 demonstrates a mitigating effect on the alcohol-induced hepatic weight gain, suggesting its potential role in counteracting the adverse impacts of acute alcohol exposure on liver morphology.
KV9 helps reduce the degree of liver damage after drinking
Experimental Study on Bifidobacterium lactis KV9
Experimental conclusion:
KV9 has demonstrated significant efficacy in protecting against liver damage induced by alcohol consumption.
The liver enzymes present in plasma, specifically aspartate aminotransferase (AST) and alanine aminotr ansf e r a s e (ALT), s e r ve a s s e n siti ve
biochemical markers that can be utilized to assess early hepatic injury. The levels of AST and ALT are indicative of the extent of liver damage; as the severity o f h e p a ti c imp a irme n t i n c r e a s e s, s o d o t h e concentrations of these enzymes. KV9 has been shown to significantly reduce the
elevation of AST and ALT levels that can occur as a result of alcohol consumption, thereby aiding the liver in mitigating the damage caused by alcohol exposure.
Lacticaseibacillus paracasei J5 can reduce the fat content in the liver.
Experimental conclusion:
In comparison to the control group, the Mod group of mice exhibited an increased accumulation of hepatic lipids. Conversely, the combined intervention group demonstrated a significant improvement in the lipid accumulation status, indicating a beneficial effect of the intervention on hepatic lipid metabolism.
Side effects of Sulfapyridine include:
Nausea, abdominal pain, diarrhea, rash, and pneumonia. Additionally, it may lead to pulmonary hemorrhage and agranulocytosis, among other complications.
Oil Red O Staining:
In routine pathological diagnosis and research activities, Oil Red O staining is commonly employed to visualize the presence of lipids within tissues. This staining technique is essential for identifying lipid accumulation and plays a crucial role in the assessment of metabolic disorders and related pathologies.
Lacticaseibacillus paracasei J5 increases alcohol metabolising enzymes in the liver
ADH (alcohol dehydrogenase), ALDH (aldehyde dehydrogenase), and CYP2E1 (cytochrome P450 2E1) are critical enzymes involved in the hepatic metabolism of ethanol. However, excessive alcohol consumption can lead to a predominant role of CYP2E1, which is recognized as a significant contributor to the induction of hepatic steatosis and oxidative stress.
The J5+Res group demonstrates a protective effect on the liver by modulating the activity of hepatic alcohol-metabolizing enzymes. In the Mod group, there is a marked reduction in the activities of both ADH and ALDH, while the activity of CYP2E1 is significantly elevated. In contrast, the results from the J5+Res group are opposite to those observed in the Mod group and show superior outcomes compared to the LP group.
Lacticaseibacillus paracasei J5 May reduce inflammatory factors
Experimental Study on Lacticaseibacillus paracasei J5